We employ a multidisciplinary approach to uncover the neuronal mechanisms controlling sleep-wake states in health and disease.

Throughout our lives, we continuously transition between wakefulness and sleep. Both states are essential for well-being, yet each comes at the expense of the other. The capacity to adaptively regulate wake and sleep periods in response to specific homeostatic and environmental conditions, such as hunger, the presence of a potential mate, or the crying of your baby, is essential for survival. 

What are the neuronal mechanisms linking motivational processes with sleep-wake regulation?

What are the neuronal substrates underlying the strong association between sleep-wake disturbances and psychiatric disorders?

The goal of our lab is to uncover the neuronal underpinnings of sleep-wake states and sleep-preparatory behaviors, and to delineate the mechanisms involved in pathological alterations in these circuits. To accomplish this, we combine innovative techniques to record and manipulate neuronal circuits in rodents, including EEG/EMG recordings, in vivo calcium imagingoptogenetics, chemogenetics, and circuit tracing with ethologically-relevant behavioral manipulations.